Resources

Software

The analytical pipeline for the lifecourse GWAS can be found here here.

Analyst Meetings

A recording of our most recent analyst meeting from March 2025 is accessible here.

A recording of a previous analyst meeting from January 2025 is accessible here.

Key papers

Morris, T. T., J. Heron, E. C. M. Sanderson, G. Davey Smith, V. Didelez, and K. Tilling. 2022. “Interpretation of Mendelian Randomization Using a Single Measure of an Exposure That Varies over Time.” Journal Article. Int J Epidemiol 51 (6): 1899–909. https://doi.org/10.1093/ije/dyac136.

Power, G. M., E. Sanderson, P. Pagoni, A. Fraser, T. Morris, C. Prince, T. M. Frayling, et al. 2024. “Methodological Approaches, Challenges, and Opportunities in the Application of Mendelian Randomisation to Lifecourse Epidemiology: A Systematic Literature Review.” Journal Article. Eur J Epidemiol 39 (5): 501–20. https://doi.org/10.1007/s10654-023-01032-1.

Richardson, T. G., E. Sanderson, B. Elsworth, K. Tilling, and G. Davey Smith. 2020. “Use of Genetic Variation to Separate the Effects of Early and Later Life Adiposity on Disease Risk: Mendelian Randomisation Study.” Journal Article. BMJ 369: m1203. https://doi.org/10.1136/bmj.m1203.

Sanderson, E., T. G. Richardson, T. T. Morris, K. Tilling, and G. Davey Smith. 2022. “Estimation of Causal Effects of a Time-Varying Exposure at Multiple Time Points Through Multivariable Mendelian Randomization.” Journal Article. PLoS Genet 18 (7): e1010290. https://doi.org/10.1371/journal.pgen.1010290.